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Conversely, non-invasive strategies maintain BBB integrity during drug delivery and rely on the transcellular pathway to improve nanomaterial transport

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Ginsenoside Rd (Rd) at a dose of 20 mg/kg effectively reduced inflammation in DSS-induced mice with colitis, and Rd downregulated the levels of pro-inflammatory cytokines including TNF-, IFN-, IL-6, and IL-17A, and IL-12/23 p40, in vivo intestinal and peritoneal macrophages and in vitro isolated intestinal and peritoneal macrophages [252]